MODELING OF THE CONTROL OF THE REGULATION OF GLUCOSE

Abstract

This article introduces the problem of glucose regulation in diabetic patients. The problem is intended to be tackled from a control systems perspective, where the measured variable is glucose in the patient and the controlled variable is infusions subcutaneous insulin. Different formulations of insulin are analyzed, which give rise to different control strategies. However, the overall goal of all them is to maintain the glucose concentration within normal conditions (70 120 mg / dl) during the 24 hrs., and also avoid extreme cases both hypoglycemia or hyperglycemia. In order to show the advantages of an automatic adjustment system dosing, closed-loop simulations using a model for a type diabetic 1.

Key Words: Diabetes, Biomedicine, Glucose Regulation physiological models, closed loop control, PID control.